10-2826
Ethacrynic acid
Größe
£158.00
- SKU:
- 10-2826
- Zusätzliche Namen:
- MK-595|NSC-85791
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 303.14
- Reinheit:
- >99%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 58-54-8
- Immunogen:
- Glutathione
- Weitere Details:
- Ethacrynic acid (58-54-8) was found to be an inhibitor of glutathione transferase P1-1 (GST P1-1) in a screen of FDA-approved drugs. It inhibits both GST P1-1 and A3-1, IC50s=4.9 and 0.4 uM respectively and apparently acts as an allosteric inhibitor.1 It forms conjugates with glutathione which also inhibit GST competitively.2 Ethacrynic acid is cytotoxic to a number of cancer cells3 and synergizes with anticancer agents like afatinib4. It is a clinically useful diuretic agent.5
- Versandbedingungen:
- Ambient