10-2768
Pomalidomide
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£149.00
- SKU:
- 10-2768
- Zusätzliche Namen:
- 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 273.24
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 19171-19-8
- Immunogen:
- Molecular glue|Ubiquitin ligase
- Weitere Details:
- Thalidomide analog. Inhibits cereblon (CRBN) an E3 ubiquitin ligase, IC50 ~3 M for CRBN-DDB1 complex.1 Displays antiangiogenic and immunomodulatory activity in vivo potently inhibiting the production of TNF and IL-2.2 Promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.3 Conjugation with other ligands is a strategy to target proteins for in vivo proteasomal degradation via PROTACS.4,5
- Versandbedingungen:
- Ambient