NSC23766

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£165.00

SKU:: 10-2731
Physischer Zustand:: Solid
Molekulargewicht:: 530.98
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 733767-34-5
Immunogen:: GPCR|GTPase
Weitere Details:: NSC-23766 is a selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) Trio and Tiam1 (IC50 ca. 50 uM) with no effect on the closely related Cdc42 or RhoA. In cells, it blocks serum or PDGF-induced Rac-1 activation and lamellipodia formation. NSC-23766 suppressed the growth of wild-type NIH 3T3 cells but was inactive in cells expressing the constitutively active Rac1 mutant, L61Rac1.1 It is a useful tool to probe the involvement of Rac1 in cell signalling.2 Off target effect: antagonist at muscarinic acetylcholine receptors.3 Cell permeable.