Splitomicin

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£153.00

SKU:: 10-2615
Physischer Zustand:: Solid
Molekulargewicht:: 198.22
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 5690-03-9
Immunogen:: Protein deacetylase
Weitere Details:: Initially shown to inhibit Sir2p (the yeast Sirt1 homolog) and create a conditional phenocopy of a sir2 deletion mutant in S. cerevisiae1. Cells grown in the presence of the drug have silencing defects at telomeres, silent mating-type loci and the ribosomal DNA1. Inhibits all class III HDACs (sirtuins) and alleviates gene silencing in Fragile X mental retardation syndrome2. Reverses ischemic preconditioning-induced cardioprotection in a mouse model3.