10-2531
SC-560
Größe
£149.00
- SKU:
- 10-2531
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 352.74
- Reinheit:
- >98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 188817-13-2
- Immunogen:
- COX (Cyclooxygenase)
- Weitere Details:
- SC-560 is a highly selective (700-fold selective over COX-2) and potent (IC50 = 9 nM) inhibitor of cyclooxygenase-1(COX-1).1 SC-560 inhibited TNFa-induced PGE2 synthesis in neurons and, PGE2 and thromboxane A2 synthesis in human monocytes and platelets (IC50's = 1.8 nM and 2.5 nM respectively) indicating non-selective COX inhibition. SC-560 was able to inhibit PGE2 synthesis in COX-1-deficient neurons indicating a COX-1 independent mechanism. This unselective COX inhibition was only observed in whole cells - it remained COX-1 specific in cell lysates.2
- Versandbedingungen:
- Ambient