10-2386
B Beta-Lapachone
Größe
£151.00
- SKU:
- 10-2386
- Zusätzliche Namen:
- NSC-26326
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 242.27
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 4707-32-8
- Immunogen:
- DNA|Topoisomerase
- Weitere Details:
- A naturally occurring quinone found in the bark of the Lapacho tree (Tabebuia avellanedae). A novel DNA topoisomerase I inhibitor which unlike camptothecin does not stabilize the cleavable complex indicating a novel mode of action.1 Induces apoptosis in a number of cancer cell lines.2 In cancer cells overexpressing NAD(P)H:quinone oxidoreductase, reduction of -lapachone leads to futile cycling between quinone and hydroquinone forms3 resulting in the production of reactive oxygen species4. Suppresses radiation-induced activation of NFB.5
- Versandbedingungen:
- Ambient