10-2148
Lenalidomide
Größe
£173.00
- SKU:
- 10-2148
- Zusätzliche Namen:
- CC-5013
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 259.26
- Reinheit:
- 98%
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 191732-72-6
- Immunogen:
- Molecular glue|Ubiquitin ligase
- Weitere Details:
- Thalidomide analog which, like thalidomide,1 binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2. Induces degradation of T-cell repressors Ikaros (IKZF1) and Aiolos (IKZF3) leading to T cell activation2. Selective inhibition of IKZF1 and IKZF3 in multiple myeloma cells results in cell death3,4. Cell permeable. Caution: Teratogenic
- Versandbedingungen:
- Ambient