10-2146
Irinotecan HCl
Größe
£158.00
- SKU:
- 10-2146
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 586.69 ∙ 36.46 ∙ 54.05
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 136572-09-3
- Immunogen:
- DNA|Topoisomerase
- Weitere Details:
- Irinotecan is a semi-synthetic derivative of camptothecin that is an FDA approved anticancer drug. It is a prodrug that is converted by tissue esterases to 7-ethyl-10-hydroxycamptothecin (SN-38), a potent inhibitor of DNA topoisomerase I.1,2 Although irinotecan is also a topoisomerase inhibitor, SN-38 is approximately 1000 times as potent in purified enzyme studies. In vitro cytotoxicity assays show much greater variability in potency between the two (2-2000 fold).3
- Versandbedingungen:
- Ambient