GW-2580

Größe

£170.00

SKU:: 10-2143
Physischer Zustand:: Solid
Molekulargewicht:: 366.32
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 870483-87-7
Immunogen:: Kinase
Weitere Details:: Potent and selective inhibitor of cFMS receptor kinase. Completely inhibits cFMS in vitro at 60 nM with no activity against 26 other kinases1. Completely inhibits CSF-1 induced growth of mouse M-NFS-60 myeloid cells and human monocytes (at 1 uM)1. Completely inhibits bone degradation in human osteoclasts, rat calvaria and fetal long bone1. Inhibits LPS-induced TNF production in mice. Abrogates infiltration of macrophages into synovial joints of arthritic mice2. Active in vivo.