Myriocin (ISP-1)

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£156.00

SKU:: 10-2088
Zusätzliche Namen:: ISP-1
Physischer Zustand:: Solid
Molekulargewicht:: 401.54
Reinheit:: >98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 35891-70-4
Immunogen:: Antibiotic
Weitere Details:: Myriocin is a fungal metabolite with potent immunosuppressant activity.1 It inhibits serine palmitoyltransferase (Ki = 0.28 nM) blocking the synthesis of ceramide.2 It was found to suppress melanoma cell proliferation by cell cycle arrest at the G 2/M phase through decreased sphingolipid levels and increased p53 and p21 (waf1/cip1) expression.3