10-2047
DRB
Größe
£134.00
- SKU:
- 10-2047
- Zusätzliche Namen:
- 5,6-Dichlorobenzimidazole riboside|NSC 401575
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 319.14
- Reinheit:
- 98%
- Aufreinigung:
- HPLC Purified
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 53-85-0
- ABP:
- No Import Docs
- Immunogen:
- Kinase|RNA
- Weitere Details:
- A classic inhibitor of transcription by RNA polymerase II. A relatively selective inhibitor of Cdk9 (IC50=3 uM), the kinase of the positive transcription elongation factor b (P-TEF-b) required for processive transcription elongation by RNA polymerase II.1,2 Also inhibits casein kinase II, IC50=4-10 uM. 3 Suppresses the SIRT1/CK2A Alpha pathway and enhances the radiosensitivity of human cancer cells.4 Kinase-independent activities of Cdk9 such as glucocorticoid receptor modulation are not inhibited by DRB.5
- Versandbedingungen:
- Ambient