10-1597
AS-8351
Größe
£149.00
- SKU:
- 10-1597
- Zusätzliche Namen:
- NSC-51355
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 291.3
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 796-42-9
- Immunogen:
- Protein demethylase
- Weitere Details:
- AS-8351 has been used in a cocktail of nine small molecules used to efficiently induce cardiac reprogramming of human fibroblasts1. It is believed that AS-8351 exerts its effects by modulating the activity of the JmjC domain-containing histone demethylases (JmjC-KDM). Thus each of the 22 genes in the JmjC-KDM family was abrogated using small hairpin RNAs which showed that only knocking down KDM5B (or using another KDM5B inhibitor such as PBIT) could phenocopy AS-8351 in generating cardiomyocytes. This strongly suggests that KDM5B is the target of AS-8351.1
- Versandbedingungen:
- Ambient