10-1560
ML323
Größe
£177.00
- SKU:
- 10-1560
- Zusätzliche Namen:
- CID 60167849|NCGC00262306
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 384.48
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1572414-83-5
- Immunogen:
- DUB (Deubiquitinating enzyme)
- Weitere Details:
- Potent and reversible USP1-UAF1 deubiquitinase complex inhibitor with excellent selectivity against human DUBs, deSUMOylase, deneddylase and unrelated proteases, IC50=76 nm in a ubiquitin-rhodamine 110 assay.1 In H1299 non-small cell lung cancer cells treatment with ML323 dose dependently and robustly increased levels of monoubiquitinated PCNA compared to untreated cells at concentrations as low as 1 M.1 It potentiates cisplatin cytotoxicity in non-small cell lung cancer and osteosarcoma cells.2 ML323 inhibition of upregulated USP1 in BRCA1-deficient tumor cells results in replication fork destabilization and decreased viability.3
- Versandbedingungen:
- Ambient