10-1558
UNC-2170 HCl
Größe
£187.00
- SKU:
- 10-1558
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 349.69
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1648707-58-7
- Immunogen:
- DNA
- Weitere Details:
- The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170, identified by screening, was found to be a uM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The compound functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1
- Versandbedingungen:
- Ambient