10-1539
ISRIB
Größe
£158.00
- SKU:
- 10-1539
- Zusätzliche Namen:
- trans-ISRIB
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 451.34
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1597403-47-8
- Immunogen:
- ER/Golgi|Ribosome|UPR (Unfolded protein response)
- Weitere Details:
- Integrated stress response inhibitor. Potently reverses the effects of initiation factor 2A Alpha (eIF2A Alpha) phosphorylation, IC50=5 nM.1 Enhances spatial and fear-associated learning in mice and enhances cognitive function.1,2 Mechanism of action involves activation of eiF2B Beta.3 Suppresses ER stress-induced inflammatory gene expression.4 Potently attenuates amyloid B Beta-induced neuronal cell death (12.5-25 nM) with no effect on amyloid B Beta production.5 Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.6
- Versandbedingungen:
- Ambient