L524-0366

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£163.00

SKU:: 10-1536
Physischer Zustand:: Solid
Molekulargewicht:: 308.79
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 951612-19-4
Weitere Details:: Fn14 antagonist. Competes with TNF-like weak inducer of apoptosis (TWEAK) C-terminal/extracellular TNF homology domain (THD) for Fn14 binding (KD = 7.12 uM). It specifically inhibits TWEAK-Fn14-mediated NFK KappaB activation. It completely suppressed TWEAK-induced T98G cell migration (10 uM) without cytotoxicity up to 50 uM1. L524-0366 is the first compound known to interfere with the TWEAK/Fn14 inter-action and may serve as a lead compound for the development of new therapeutics2.