10-1504
FLI-06
Größe
£163.00
- SKU:
- 10-1504
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 438.52
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 313967-18-9
- Immunogen:
- ER/Golgi
- Weitere Details:
- FLI-06 was discovered in a screen designed to monitor the trafficking and processing of a ligand-independent Notch-enhanced GFP reporter. It disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and inhibited general secretion at a step before exit from the ER which was accompanied by a tubule-to-sheet morphological transition of the ER and is thus a novel agent acting at an early stage in secretory traffic (EC50=2.3 M).1 Abolishes MFAP5-dependent transcriptional programs which are upregulated in intrahepatic cholangiocarcinoma.2 Suppresses proliferation and induces apoptosis in esophogeal squamous cell carcinoma cells.3
- Versandbedingungen:
- Ambient