XIB4035

Größe

£158.00

SKU:: 10-1486
Physischer Zustand:: Solid
Molekulargewicht:: 750.45
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 10023-54-8
Weitere Details:: A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor A Alpha-1 GFRA Alpha-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 uM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRA Alpha family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson's disease therapeutics.4