PRT4165

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£163.00

SKU:: 10-1478
Physischer Zustand:: Solid
Molekulargewicht:: 235.24
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 31083-55-3
Immunogen:: Ubiquitin ligase
Weitere Details:: Inhibitor of Bmi1/Ring1A, subunits of the polycomb repressive complex 1 (PRC1). Inhibits self-ubiquitination (IC50 = 3.9 uM) but does not increase cellular levels of either subunit. Blocks Bmi1/Ring1A-mediated ubiquitination and drug-induced degradation of topoisomerase 2A Alpha.1 Inhibits H2A/H2AX ubiquitination via blocking the E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex. Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination in vitro and in vivo and as such represents a new tool for studying chromatin remodeling.2