Salirasib

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£134.00

SKU:: 10-1461
Physischer Zustand:: Solid
Molekulargewicht:: 358.54
Reinheit:: >98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 162520-00-5
Immunogen:: GTPase
Weitere Details:: Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3. It has been investigated in the treatment of various cancers.4,5 HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis.6 Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 uM).7