GSK-1702934A

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£158.00

SKU:: 10-1445
Physischer Zustand:: Solid
Molekulargewicht:: 396.53
Reinheit:: 98%
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 924377-85-5
Immunogen:: Ion channel
Weitere Details:: TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 uM and 0.44 uM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1uM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1uM.1 Induces pro-arrhythmic and inotropic effects in TRPC3-overexpressing monocytes.2