BI-6015

Größe

£149.00

SKU:: 10-1402
Physischer Zustand:: Solid
Molekulargewicht:: 331.35
Reinheit:: 98%
Lagerbedingungen:: -20[o]C
Hersteller:: Focus Biomolecules
CAS Number:: 93987-29-2
Immunogen:: Transcription factor
Weitere Details:: Hepatocyte nuclear factor 4A Alpha (HNF4A Alpha) antagonist. HNF4A Alpha is a central regulator of gene expression in cell types that play a central role in metabolic homeostasis. 1 BI-6015 binds to HNF4A Alpha with high affinity and modulates the expression of known target genes. It was shown to be selectively cytotoxic to cancer cell lines in vitro and in vivo however in vivo potency was limited by suboptimal pharmacokinetics. 2 Represents the first small molecule tool for pharmacologic modulation of HNF4A Alpha activity. 2 Cell permeable.