10-1394
GSK-J4
Größe
£149.00
- SKU:
- 10-1394
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 417.48
- Reinheit:
- 99%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 1373423-53-0
- Immunogen:
- Protein demethylase
- Weitere Details:
- Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 uM for the inhibition of TNFA Alpha release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
- Versandbedingungen:
- Ambient