10-1371
iCRT5
Größe
£155.00
- SKU:
- 10-1371
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 367.44
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 18623-44-4
- Immunogen:
- Transcription factor
- Weitere Details:
- A selective CRT (B Beta-catenin-responsive transcription) inhibitor.1 IC50=18 nM for Wnt responsive STF16 luciferase. Acts via interfering with the B Beta-catenin, TCF4 interaction.1 Displays poor inhibition of cell proliferation in triple-negative breast cancer cells.2 Increases the surface expression of MHCII, CD80 and CD86 on unstimulated dendritic cells (DCs) with no detrimental effects on immune-phenotype of stimulated DCs.3 Modulators of Wnt signaling show great promise in animal models of several cancers.4 Cell permeable.
- Versandbedingungen:
- Ambient