BIX-01294

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£158.00

SKU:: 10-1335
Physischer Zustand:: Solid
Molekulargewicht:: 600.02
Reinheit:: >98%
Aufreinigung:: HPLC Purified
Lagerbedingungen:: RT
Hersteller:: Focus Biomolecules
CAS Number:: 935693-62-2
Immunogen:: Protein methyltransferase
Weitere Details:: BIX-01294 is a selective inhibitor of G9a histone methyltransferase (G9aHMTase; IC50 = 1.7 uM) as well as GLP HMTase (IC50 = 38 uM) leading to a decrease in H3K9me2(histone H3 lysine 9 methylation) in vitro.1 BIX-01294 facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells.3