10-1311
MLN4924
Größe
£147.00
- SKU:
- 10-1311
- Zusätzliche Namen:
- Pevonedistat
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 443.53
- Reinheit:
- 98%
- Lagerbedingungen:
- -20[o]C
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 905579-51-3
- Immunogen:
- Neddylation
- Weitere Details:
- MLN4924 is a potent and selective NEDD8-activating enzyme (NAE) inhibitor.1 It disrupts cullin-RING ligase-mediated protein turnover leading to apoptosis in human tumor cells. Suppresses the growth of human tumor xenografts in mice.2 Upregulates PD-L1 expression and enhances the efficacy of immune checkpoint blockade in glioblastoma.3 Modulates tumor microenvironment.4 Blocks the neddylation of the DNA endonuclease CtIP, which promotes HDR in Cas9- and Cpf1-mediated gene editing. Part of the CRISPY mix for increasing precise gene editing.5 Cell permeable.
- Versandbedingungen:
- Ambient