10-1192
PIT-1
Größe
£134.00
- SKU:
- 10-1192
- Physischer Zustand:
- Solid
- Molekulargewicht:
- 351.76
- Reinheit:
- 98%
- Lagerbedingungen:
- RT
- Hersteller:
- Focus Biomolecules
- CAS Number:
- 53501-41-0
- Immunogen:
- Kinase
- Weitere Details:
- PH domain antagonist. Specifically blocks the binding of PIP3 to the Akt pleckstrin homology domain (IC50 = 31 uM). Suppresses PI3K-PDK1-Akt-dependent phosphorylation. Induces apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 uM)1. Inhibiting the binding of PIP3 to effector PH domains is new point of intervention in the PI3K signaling network2.
- Versandbedingungen:
- Ambient