E-OSEL-S0001
QuicKey Pro Sheep E2(Estradiol) ELISA Kit
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£128.70
War £143.00
- SKU:
- E-OSEL-S0001
- Zusätzliche Namen:
- 17B Beta-Estradiol,17B Beta-diol,3,5(10) -triene-3,E2,Estra-1,Oestradiol
- Anwendung:
- ELISA
- Physischer Zustand:
- Plasma, Serum
- Spezies-Reaktivität:
- Sheep
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Format:
- Colorimetric method,ELISA,Competitive
- Weitere Details:
- Evidence, accumulated over the past 25 years, shows that estradiol modulates cognitive function in animals and humans. Modulation begins in utero when estrogens direct sexual differentiation of various brain regions controlling reproduction and some cognitive functions. Gonadal hormone influences on the nervous system, including both estrogens and androgens, continue through adolescence and reach their zenith at adulthood when gonadal hormone secretions reach the highest levels. With aging, levels of circulating estrogens plummet and appear to contribute to age-related declines in learning and memory function. These hormone-dependent effects on cognition over the lifespan have been attributed to classic, genomic mechanisms - hormone binding to specific receptors, alterations in gene transcription and the initiation of organ-specific effects in target areas in the brain and peripheral organs. More recently, it has also been established that gonadal hormones, including estradiol, can act at membrane receptors to activate intra-cellular signaling mechanisms which alter cellular function. Moreover, there is increasing documentation that gonadal hormones are neurosteroids, that is, estrogens and androgens are synthesized locally in brain areas and thereby rapidly alter cognition and other neural functions. The physiological functions and implications for this mode of estrogen action are unknown at this time but present a novel area for investigation. Finally, in a more global way, estradiol also acts indirectly to maintain cognitive functions because it exerts neurotrophic effects within the brain. Thus, gonadal hormones, estradiol in particular, have a rich repertoire of possible mechanisms for influencing cognition.
- Versandbedingungen:
- Blue Ice