QuicKey Pro Human DPP4 (Dipeptidyl Peptidase IV) ELISA Kit

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£120.60

War £134.00

SKU:: E-OSEL-H0084
Zusätzliche Namen:: CD26,DPPIV,ADABP,ADCP2,TP103,Adenosine Deaminase Complexing Protein 2
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Human
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Reaktivitäten:: Human
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P27487
Synonyme:: ADABP;ADCP-2;ADCP2;adenosine deaminase complexing protein 2;CD26;dipeptidyl peptidase 4;dipeptidyl peptidase IV;dipeptidylpeptidase 4;dipeptidylpeptidase IV (CD26, adenosine deaminase complexing protein 2);DPP IV;DPPIV;Gly-Pro naphthylamidase;Post-proline dipeptidyl aminopeptidase IV;T-cell activation antigen CD26;TP103;Xaa-Pro-dipeptidylaminopeptidase
Weitere Details:: Dipeptidyl Peptidase IV (DPPIV, also CD26 and adenosine deaminase complexing protein 2) is a serine protease that releases Xaa-Pro dipeptides from the N-terminus of oligo- and polypeptides. As a type II membrane protein, it includes a small cytoplasmic tail, a transmembrane region, and a large extracellular domain with glycosylation sites, a cysteine-rich region, and a Ser-Asp-His catalytic active site. Native DPPIV exists as a non-covalently linked homodimer on cell surfaces, with its soluble form (intact extracellular domain) present in human serum and other body fluids. DPPIV plays a key role in multiple physiological and pathological processes: it interacts with ADA and CD45 to co-stimulate the CD3/T-cell receptor complex, cleaves N-terminal Xaa-Pro-containing chemokines, altering their receptor specificity and function, degrades peptide hormones (e.g., glucagon-like peptide-1) to reduce bioactivity, with DPPIV inhibitors for type 2 diabetes in late-stage clinical trials, truncates procalcitonin (a marker for systemic bacterial/fungal infections), and interacts with HIV-1 Tat protein, whose ADA binding is inhibited by HIV envelope protein gp120.

Versandbedingungen:: Blue Ice