E-KAB-0719
Human IL-37 Antibody Pair Set
Größe
£793.80
War £882.00
- SKU:
- E-KAB-0719
- Zusätzliche Namen:
- IL37,FIL1,FIL1(ZETA),FIL1Z,IL-1F7,IL-1H,IL-1H4,IL-1RP1,IL-37,IL1F7,IL1H4,IL1RP1
- Anwendung:
- ELISA
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Reaktivitäten:
- Human
- Buffer:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Immunogen:
- IL-37
- Formulierung:
- Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
- Uniprot:
- Q9NZH6
- Synonyme:
- FIL1;FIL1 zeta;FIL1(ZETA);FIL1Z;IL-1 zeta;IL-1F7;IL-1F7b (IL-1H4, IL-1H, IL-1RP1);IL-1H;IL-1H4;IL-1RP1;IL-1X;IL-1X protein;IL-23;IL-37;IL1F7;IL1F7 (canonical product IL-1F7b);IL1H4;IL1RP1;interleukin 1 family member 7;interleukin 1, zeta;Interleukin-1 family member 7;interleukin-1 homolog 4;interleukin-1 superfamily z;Interleukin-1 zeta;interleukin-1-related protein;interleukin-23;interleukin-37
- Weitere Details:
- IL-37,also known as IL-1F7,belongs to the IL-1 family. There are five isoforms generated by alternative splicing,identified as IL-37a-e. IL-37b is the largest isoform and IL-37a contains a unique N-terminal sequences,absent in other isoforms. IL-37 is exclusively expressed only in human cells,but not found in murine cells. IL-37 isoforms are expressed in a tissue-specific manner. Its expression is upregulated upon LPS stimulation as well as TLR agonists in human blood monocytes and macrophages,whereas it is downregulated by IL-12,IL-32 and combination of GM-CSF and IL-4. IL-37 has been shown to translocate to the nucleus upon LPS treatment. IL-37 is a broad anti-inflammatory cytokine. IL-37a and IL-37b inhibits LPS-treated pro-inflammatory cytokine production in M1-differentiated macrophages and dendritic cells via IL-18RA Alpha and SIGIRR/IL-1R8.
- Versandbedingungen:
- Blue Ice