Human RANK KappaL Antibody Pair Set

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£793.80

War £882.00

SKU:: E-KAB-0694
Zusätzliche Namen:: TNFSF11,TRANCE,RANKL,CD254,ODF,OPGL,OPTB2,hRANKL2,sOdf
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Reaktivitäten:: Human
Buffer:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Immunogen:: RANκL
Formulierung:: Capture Antibody:PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4, Detection Antibody:PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.4
Uniprot:: O14788
Synonyme:: CD254;hRANKL2;Ly10;Ly109l;O;OD;ODF;OPG ligand;OPGL;OPTB2;osteoclast differentiation factor;osteoprotegerin ligand;R;RANKL;receptor activator of NF-kappaB ligand;receptor activator of nuclear factor kappa B ligand;receptor activator of nuclear factor kappa-B ligand;sOdf;TNF-related activation-induced cytokine;TNLG6B;Tra;TRANCE;tumor necrosis factor (ligand) superfamily, member 11;tumor necrosis factor ligand 6B;tumor necrosis factor ligand superfamily member 11;tumor necrosis factor superfamily member 11;tumor necrosis factor-related activation-induced cytokine
Weitere Details:: RANKL gene encodes a type II membrane protein of 316 amino acids with a predicted molecular mass of 35 kD. RANKL is cleaved to produce a soluble form with biological activity. The shedding of membrane-bound RANKL appears to be mediated by expression of MMP14 and ADAM10. Suppression of MMP14 in primary osteoblasts increases membrane-bound RANKL and promotes osteoclastogenesis in cocultures with macrophages. Therefore,RANKL shedding seems to be an important process that down-regulates local osteoclastogenesis. Alternatively,an increased production of RANKL by osteoblastic cells leads to osteoclast differentiation,activation,and survival,which results in increased bone resorption. Binding of RANKL to its receptor RANK activates TNF receptor-associated factor 6 (TRAF6),which is linked to downstream pathways including NF-K KappaB,c-jun N-terminal kinase (JNK) or Src.

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