Human IL-23 Antibody Pair Set

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£460.80

War £512.00

SKU:: E-KAB-0464
Zusätzliche Namen:: IL-23A,IL23P19,P19,SGRF
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Human
Lagerbedingungen:: -20[o]C Avoid freeze/thaw cycles.
Hersteller:: Elabscience
Reaktivitäten:: Human
Buffer:: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
Immunogen:: IL-23
Formulierung:: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
Uniprot:: P29460
Synonyme:: CLMF;CLMF p40;CLMF2;cytotoxic lymphocyte maturation factor 40 kDa subunit;IL-12 subunit p40;IL-12B;IL12, subunit p40;IMD28;IMD29;interleukin 12, p40;interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40);interleukin-12 beta chain;interleukin-12 subunit beta;natural killer cell stimulatory factor, 40 kD subunit;NK cell stimulatory factor chain 2;NKSF;NKSF2
Weitere Details:: Interleukin-12 ( IL-12 ) ,is a cytokine that is secreted by activated phagocytes and dendritic cells and that induces interferon-G Gammaproduction by natural-killer and T lymphocytes. IL-12 is a 75 kDa heterodimer composed of a 35 kDa subunit ( IL-12A p35 ) and a 40 kDa subunit ( IL-12B p40 ) that is secreted by a wide variety of antigen presenting cells ( APCs ) ,including phagocytes,B cells and Langerhans cells. IL-12B has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of IL-12B was observed in the central nervous system of patients with multiple sclerosis ( MS ) ,suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of IL-12B has been reported to be associated with the severity of atopic and non-atopic asthma in children.

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