E-KAB-0440
Human VEGFR3/Flt4 Antibody Pair Set
Größe
£460.80
War £512.00
- SKU:
- E-KAB-0440
- Zusätzliche Namen:
- FLT41,PCL,LMPH1A
- Anwendung:
- ELISA
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Reaktivitäten:
- Human
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- VEGFR3/Flt4
- Formulierung:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P35916
- Synonyme:
- CHTD7;Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4;FLT-4;FLT41;fms related tyrosine kinase 4;fms-like tyrosine kinase 4;LMPH1A;LMPHM1;PCL;primary congenital lymphedema;tyrosine-protein kinase receptor FLT4;vascular endothelial growth factor receptor 3;VEGF receptor-3;VEGFR-3;VEGFR3
- Weitere Details:
- Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD , and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation , survival and migration of endothelial cells , and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC , and to a lesser degree VEGFA , thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades , isoform 2 seems to be less efficient in signal transduction , because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2 , MAPK3/ERK1 signaling pathway , of MAPK8 and the JUN signaling pathway , and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1 , the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185' , and of AKT1 at 'Ser-473'
- Versandbedingungen:
- Blue Ice