E-KAB-0398
Canine IFN-G Gamma Antibody Pair Set
Größe
£793.80
War £882.00
- SKU:
- E-KAB-0398
- Zusätzliche Namen:
- IFNG,IFG,IFI,Type II Interferon
- Anwendung:
- ELISA
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Spezies-Reaktivität:
- Canine
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Reaktivitäten:
- Canine
- Buffer:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Immunogen:
- IFN-γ
- Formulierung:
- PBS with 0.04% Proclin 300, 50% glycerol, pH 7.5, PBS with 0.04% Proclin 300, 1% protective protein, 50% glycerol, pH 7.5
- Uniprot:
- P42161
- Synonyme:
- IFN-G;IFN-gamma;interferon gamma
- Weitere Details:
- Type II interferon produced by immune cells such as T-cells and NK cells that plays crucial roles in antimicrobial , antiviral , and antitumor responses by activating effector immune cells and enhancing antigen presentation. Primarily signals through the JAK-STAT pathway after interaction with its receptor IFNGR1 to affect gene regulation. Upon IFNG binding , IFNGR1 intracellular domain opens out to allow association of downstream signaling components JAK2 , JAK1 and STAT1 , leading to STAT1 activation , nuclear translocation and transcription of IFNG-regulated genes. Many of the induced genes are transcription factors such as IRF1 that are able to further drive regulation of a next wave of transcription. Plays a role in class I antigen presentation pathway by inducing a replacement of catalytic proteasome subunits with immunoproteasome subunits. In turn , increases the quantity , quality , and repertoire of peptides for class I MHC loading. Increases the efficiency of peptide generation also by inducing the express
- Versandbedingungen:
- Blue Ice