E-EL-R2584
Rat LDLR(Low Density Lipoprotein Receptor) ELISA Kit
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£128.70
War £143.00
- SKU:
- E-EL-R2584
- Zusätzliche Namen:
- FH,FHC,LDLCQ2,Familial Hypercholesterolemia
- Anwendung:
- ELISA
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Spezies-Reaktivität:
- Rat
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P35952
- Synonyme:
- LDL receptor;LDLRA;low-density lipoprotein receptor
- Weitere Details:
- The Low-Density Lipoprotein Receptor (LDLR) is the founding member of the LDLR family of widely expressed cell surface scavenger receptors . Many proteins in the LDLR family are cleaved by extracellular proteases to release soluble forms into the circulation, and many of these soluble forms are active . Mature LDLR is a 160 kDa type I transmembrane glycoprotein that contains cysteine-rich complement-like repeats (class A LDLR domains), calcium-binding EGF repeats, and B Beta-propeller structures (class B LDLR domains) in the ECD. LDLR is constitutively and widely expressed. Its expression can be downregulated by LDL and upregulated by hormones such as insulin and estradiol, and by many cytokines. Hepatocyte LDLR is responsible for endocytosis and clearing of most plasma LDL cholesterol. LDLR binds the ApoB portion of LDL and brings it into endocytic vesicles. It dissociates at the low pH of the vesicle, allowing LDL to be degraded while LDLR is recycled back to the cell surface. Lack of LDLR expression or function causes familial hypercholesterolemia (FH), over 1100 FH-related LDLR mutations have been identified. Overexpression or hyperfunction of the protease PCSK9 can also cause increased plasma cholesterol by lowering cell surface LDLR expression.PCSK9 alters the pH-induced LDLR conformation change in the endocytic vesicle, thus promoting LDLR degradation rather than recycling to the cell surface .
- Versandbedingungen:
- Blue Ice