Rat sCD14(Soluble Cluster of Differentiation 14) ELISA Kit

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£128.70

War £143.00

SKU:: E-EL-R0888
Zusätzliche Namen:: CD14 Antigen,Monocyte Differentiation Antigen CD14
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Rat
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: Q63691
Synonyme:: CD14 antigen;monocyte differentiation antigen CD14;myeloid cell-specific leucine-rich glycoprotein
Weitere Details:: CD14 is a pattern recognition receptor important in innate immunity. CD14 exists in two forms, as a glycosylphosphatidylinositol-anchored protein on the surface of mononuclear cells and as a soluble protein in the blood. CD14 is shed from the surface of CD14-expressing cells, resulting in the soluble CD14 protein (sCD14). Membrane associated CD14 is a pro-inflammatory co-receptor for LPS, a characteristic constituent of the cell wall of Gram-negative bacteria. LPS interacts with LPS-binding protein (LBP) and CD14, and this complex interacts with TLR4, which subsequently induces inflammatory gene expression through NF-K KappaB and mitogen-activated protein-kinase signaling in host cells. sCD14 enables responses to LPS by cells that do not express CD14 such as endothelial cells.