Mouse MCSFR (Macrophage colony-stimulating factor 1 receptor) ELISA Kit

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£120.60

War £134.00

SKU:: E-EL-M3129
Zusätzliche Namen:: CSF-1 receptor,CSF-1-R,CSF-1R,M-CSF-R,Proto-oncogene c-Fms,CD115
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Mouse
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Reaktivitäten:: Mouse
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P09581
Synonyme:: AI323359;c-fms;CD115;Csf;CSF-;CSF-1 receptor;CSF-1-R;CSF-1R;Csfmr;Fim;Fim-;Fim-2;Fim2;Fm;Fms;M-CS;M-CSF-R;M-CSFR;macrophage colony-stimulating factor 1 receptor;proto-oncogene c-Fms;proto-oncogene fms
Weitere Details:: MCSFR(Macrophage colony-stimulating factor 1 receptor), also known as CD115 and CSF1R, is a single-pass type I membrane tyrosine-protein kinase and a member of the platelet-derived growth factor receptor family. It acts as a cell-surface receptor for CSF1 (M-CSF) and IL34, playing essential roles in regulating survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes, osteoclasts, and microglia. It mediates innate immunity, inflammatory processes, normal bone/tooth development, and mammary gland maturation during pregnancy. Ligand binding induces its homodimerization, phosphorylation and activation of downstream pathways (ERK1/2, JNK, AKT1), and promotes cancer cell invasion. It is expressed on monocytes/macrophages, dendritic cells and osteoclasts.