Mouse Lptn/XCL1(Lymphotactin) ELISA Kit

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£128.70

War £143.00

SKU:: E-EL-M0763
Zusätzliche Namen:: SCYC1,LTN,ATAC,SCM-1a,SCM-1,Chemokine(C motif) ligand,XCL1,Lptn
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Mouse
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Format:: Colorimetric method,ELISA,Sandwich
Uniprot:: P47993
Synonyme:: AI661682;AT;ATAC;c motif chemokine 1;chemokine XCL1;cytokine SCM-1;L;Lptn;LTN;lymphotactin;lymphotaxin;SCM-;SCM-1;SCM-1a;Scyc;Scyc1;small inducible cytokine subfamily C, member 1 (lymphotactin);small-inducible cytokine C1
Weitere Details:: XCL1, also known as lymphotactin, is an inflammatory chemokine secreted by T cells and natural killer (NK) cells. The XCL1-XCR1 axis has been shown to play an important role in the dendritic cell mediated cytotoxic immune response and in the formation of self-tolerance mechanisms through the development of regulatory T cells within the thymus. XCL1 also acts as a conformation-dependent inhibitor of HIV-1. Unlike other chemokines, XCL1 conformation interchanges between conserved chemokine folds and an unrelated dimeric structure under physiological conditions. The XCL1 monomer binds XCR1 with a high affinity, whereas the dimer form binds glycosaminoglycans (GAGs) with a high affinity, but fails to activate XCR1.