E-EL-H0237
Human AR(Amphiregulin) ELISA Kit
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£128.70
War £143.00
- SKU:
- E-EL-H0237
- Zusätzliche Namen:
- AREG,CRDGF,SDGF
- Anwendung:
- ELISA
- Physischer Zustand:
- Other Biological Fluid, Plasma, Serum
- Spezies-Reaktivität:
- Human
- Lagerbedingungen:
- 2-8[o]C
- Hersteller:
- Elabscience
- Format:
- Colorimetric method,ELISA,Sandwich
- Uniprot:
- P15514
- Synonyme:
- amphiregulin;amphiregulin B;AR;AREGB;colorectum cell-derived growth factor;CRDGF;schwannoma-derived growth factor;SDGF
- Weitere Details:
- Amphiregulin was initially identified in the conditioned medium of human mammary gland MCF-7 cells treated with TPA. The mouse gene was cloned from the androgen-dependent SC2G cell line derived from Shionogi mouse mammary carcinoma SC115. It belongs to the EGF family of proteins that includes EGF, TGF-A Alpha, heparin-binding EGF like-growth factor (HB-EGF), epigen, epiregulin, and betacellulin. Mouse amphiregulin is derived from a 248 amino acid transmembrane precursor and it has 66% identity to the human protein. All the EGF family members are synthesized as type I membrane protein precursors, which can undergo proteolytic cleavage at the plasma membrane to release a mature soluble ectodomain. ADAM17 (TACE) has an important role in ectodomain shedding of amphiregulin, TNF-A Alpha, and HB-EGF. This cleavage is a key step in the control of ligand availability and receptor activation.
- Versandbedingungen:
- Blue Ice