3-NT(3-Nitrotyrosine) ELISA Kit

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£128.70

War £143.00

SKU:: E-EL-0040
Zusätzliche Namen:: 3-Nitro-L-Tyrosine,Nitrotyrosine
Anwendung:: ELISA
Physischer Zustand:: Other Biological Fluid, Plasma, Serum
Spezies-Reaktivität:: Wide/Non-species Specific
Lagerbedingungen:: 2-8[o]C
Hersteller:: Elabscience
Format:: Colorimetric method,ELISA,Competitive
Weitere Details:: 3-nitrotyrosine modification of proteins is a wellestablished marker of protein damage by oxidative stress. 3-nitrotyrosine is a product of protein tyrosine nitration resulting fromoxidative damage to proteins by peroxynitrite. Peroxynitrite is a formedin vivo by the reaction of nitric oxide, a cellular messenger, andsuperoxide, the majority of which is generated by the mitochondrialrespiratory chain. 3-nitrotyrosine modification of proteins can result inchanges in protein structure, function and catalytic activity. Tyrosinenitration may increase (e.g. sGC, Src, PI3K, Akt), decrease (e.g. MnSOD, Ca++-ATPase), or have no discernable effect (e.g. p53, VASP, A AlphaSynuclein) on the activity of a particular protein. Tyrosine nitration hasbeen implicated in the pathogenesis of major neurological(Alzheimer's, Parkinson's, multiple sclerosis, and stroke) andcardiovascular (atherosclerosis, myocardial infarction, coronary arterydisease, hypertension) diseases that share inflammation as acontributor to pathogenesis.