E-AB-F1381E
APC Anti-Human CD158b/j Antibody[DX27]
Größe
£115.20
War £128.00
- SKU:
- E-AB-F1381E
- Anwendung:
- Flow Cytometry
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- CD158b/j
- Klon:
- DX27
- Uniprot:
- P43627, P43628
- Synonyme:
- CD158 antigen-like family member B1;CD158 antigen-like family member B2;CD158b;CD158B1;CD158B2;GL183;killer cell immunoglobulin-like receptor 2DL2;killer cell immunoglobulin-like receptor 2DL3;killer cell immunoglobulin-like receptor two domains long cytoplasmic tail 3;killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 2;killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 5;killer inhibitory receptor cl 2-3;KIR-023GB;KIR-K7b;KIR-K7c;KIR2DL;KIR2DS5;KIRCL23;MHC class I NK cell receptor;natural killer associated transcript 2;natural killer cell inhibitory receptor KIR2DL3;Natural killer-associated transcript 2;natural killer-associated transcript 6;NKAT;NKAT-2;NKAT-6;NKAT2;NKAT2A;NKAT2B;NKAT6;p58;p58 natural killer cell receptor clone CL-43;p58 natural killer cell receptor clone CL-6;p58 NK receptor CL-43;p58 NK receptor CL-6;p58.2;p58.2 MHC class-I specific NK receptor;p58.2 MHC class-I-specific NK receptor
- Weitere Details:
- CD158b is expressed on natural killer cells and a subset of T cells. It is a member of the immunoglobulin superfamily containing two immunoglobulin C2-type domains. Both variants and alternative isoforms of CD158b have been reported. The interaction of CD158b with specific HLA-C antigens on a target cell (HLA-Cw1, HLA-Cw3, HLA-Cw7 alleles, for example) inhibits cytotoxicity and prevents target cell lysis and death. The interactions between KIR and MHC class I are thought to be important in NK cell and T cell regulation following antigen stimulation. The absence of ligands for KIRs may lower the threshold for activation through activating receptors and increase inflammation and susceptibility to autoimmune disease.
- Versandbedingungen:
- Blue Ice