APC Anti-Human CD101 Antibody[BB27]

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£115.20

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SKU:: E-AB-F1361E
Zusätzliche Namen:: P126,V7
Anwendung:: Flow Cytometry
Lagerbedingungen:: 2-8[o]C Do not freeze.
Hersteller:: Elabscience
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS
Immunogen:: CD101
Klon:: BB27
Uniprot:: Q93033
Synonyme:: cell surface glycoprotein V7;EWI-101;glu-Trp-Ile EWI motif-containing protein 101;IGSF2;immunoglobulin superfamily member 2;leukocyte surface protein;V7
Weitere Details:: CD101 is a type I transmembrane glycoprotein, known as V7, and P126. It is a 120 kD homodimer, the member of EWI family within Ig superfamily. CD101 is found on monocytes, granulocytes, dendritic cells, a subpopulation of peripheral blood T cells and activated T cells. It has been reported that CD101 expressing Tregs posses higher inhibitory function. The biological function of CD101 is still not clear. But it has been found that BB27 antibody is able to inhibit T cell proliferative responses and this inhibitory function can be overcome by high doses of IL-2. Activation of CD101 on dendritic cells is able to induce IL-10 production.