E-AB-F13530
Purified Anti-Mouse CD4 Antibody[RM4-5], Functional Grade
Größe
£80.10
War £89.00
- SKU:
- E-AB-F13530
- Zusätzliche Namen:
- L3T,T-cell surface antigen T4/Leu,T-cell surface glycoprotein CD,L3T4,Ly-4,T4,T-cell surface antigen T4/Leu-3,T-cell surface glycoprotein CD4,Cd4, L3T4,CD4mut,p55
- Anwendung:
- Flow Cytometry
- Konzentration:
- >= 1 mg/ml
- Aufreinigung:
- protein a/g purified
- Lagerbedingungen:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rat
- Reaktivitäten:
- Mouse
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- Immunogen:
- Recombinant Mouse CD4 protein
- Klon:
- RM4-5
- Uniprot:
- P06332
- Synonyme:
- L3T;L3T4;Ly-;Ly-4;T-cell differentiation antigen L3T4;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
- Versandbedingungen:
- Blue Ice