E-AB-F12860
Purified Anti-Mouse CD172a Antibody[P84], Functional Grade
Größe
£80.10
War £89.00
- SKU:
- E-AB-F12860
- Zusätzliche Namen:
- Myd,SHPS,Ptpns,Bit,Myd1,Ptpns1,Shps1,Sirp,Sirpa, SIRP&,beta-1-1,SIRP&,alpha,SIRP&,beta,AI835480,CD172a,P84,SHP-1,SHPS-1
- Anwendung:
- Flow Cytometry
- Konzentration:
- >= 1 mg/ml
- Aufreinigung:
- protein a/g purified
- Lagerbedingungen:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rat
- Reaktivitäten:
- Mouse
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- Immunogen:
- Recombinant Mouse CD172a protein
- Klon:
- P84
- Uniprot:
- P97797
- Synonyme:
- AI835480;Bi;Bit;brain Ig-like molecule with tyrosine-based activation motifs;brain immunological-like with tyrosine-based motifs;CD172;CD172 antigen-like family member A;CD172a;Idd13.2;inhibitory receptor SHPS-1;mSIRP-alpha1;myD-1 antigen;P8;P84;protein tyrosine phosphatase, non-receptor type substrate 1;Pt;Ptpns1;SHP;SHP substrate 1;SHP-1;SHPS-1;signal-regulatory protein alpha-1;SIRP;sirp-alpha-1;tyrosine-protein phosphatase non-receptor type substrate 1
- Weitere Details:
- Immunoglobulin-like cell surface receptor for CD47. Acts as a docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization. Receptor for THBS1. Interaction with THBS1 stimulates phosphorylation of SIRPA. In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
- Versandbedingungen:
- Blue Ice