APC Anti-Human/Monkey CD28 Antibody[CD28.2]

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£72.90

War £81.00

SKU:: E-AB-F1195E
Zusätzliche Namen:: GPSAT,GYPA,HGpMiX,MNS,PAS2
Anwendung:: Flow Cytometry
Lagerbedingungen:: 2-8[o]C Do not freeze. Protect from light.
Hersteller:: Elabscience
Host:: Mouse
Reaktivitäten:: Human
Buffer:: PBS
Immunogen:: CD28
Klon:: CD28.2
Uniprot:: P10747
Synonyme:: T-cell-specific surface glycoprotein CD28;Tp44
Weitere Details:: CD28 is a 44 kD disulfide-linked homodimeric type I glycoprotein. It is a member of the immunoglobulin superfamily and is also known as T44 or Tp44. CD28 is expressed on most T lineage cells, NK cell subsets, and plasma cells. CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL-2 synthesis, and preventing cell death. In vitro studies indicate that ligation of CD28 on T cells by CD80 and CD86 on antigen presenting cells provides a costimulatory signal required for T cell activation and proliferation.