PE Anti-Mouse FcE EpsilonRIA Alpha Antibody[MAR-1]

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£74.70

War £83.00

SKU:: E-AB-F1188D
Zusätzliche Namen:: Fc-epsilon RI-alpha,FcERI,Fcer1a,High affinity immunoglobulin epsilon receptor subunit alpha
Anwendung:: Flow Cytometry
Lagerbedingungen:: 2-8[o]C Do not freeze. Protect from light.
Hersteller:: Elabscience
Host:: Hamster
Reaktivitäten:: Mouse
Buffer:: PBS
Immunogen:: FcεRIα
Klon:: MAR-1
Uniprot:: P20489
Synonyme:: fc-epsilon RI-alpha;FcE;Fce1;Fce1a;fcepsilonri;FcERI;Fcr-;Fcr-5;high affinity immunoglobulin epsilon receptor subunit alpha;igE Fc receptor subunit alpha
Weitere Details:: FcE EpsilonRIA Alpha is a transmembrane protein belonging to the Ig superfamily. FcE EpsilonRIA Alpha forms a tetrameric complex with one B Beta and two G Gamma-subunits. The FcE EpsilonRI complex plays an important role in triggering IgE-mediated allergic reactions. It is abundantly expressed on mast and basophils and up-regulated by the presence of IgE. Following stimulation via FcE EpsilonRIA Alpha, mast cells and basophils release bioactive chemical mediators such as histamine, resulting in the initiation of allergic reactions. Cross linking of the high-affinity receptor for IgE on tissue mast cells triggers immediate hypersensitivity with local symptoms. The MAR-1 monoclonal antibody reacts with the FcE EpsilonRIA Alpha subunit.