E-AB-F1158D
PE Anti-Human/Monkey CD196/CCR6 Antibody[G034E3]
Größe
£108.00
War £120.00
- SKU:
- E-AB-F1158D
- Zusätzliche Namen:
- CMKBR6,GPR29,STRL22,CKRL3,GPRCY4,CCR6
- Anwendung:
- Flow Cytometry
- Lagerbedingungen:
- 2-8[o]C Do not freeze. Protect from light.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- PBS
- Immunogen:
- CD196/CCR6
- Klon:
- G034E3
- Uniprot:
- P51684
- Synonyme:
- BN-1;C-C chemokine receptor type 6;C-C CKR-6;CC-CKR-6;CCR-6;CD196;chemokine (C-C motif) receptor 6;chemokine (C-C) receptor 6;chemokine receptor-like 3;CKR-L3;CKRL3;CMKBR6;DCR2;DRY6;G protein-coupled receptor 29;G-protein coupled receptor 29;GPR-CY4;GPR29;GPRCY4;LARC receptor;seven-transmembrane receptor, lymphocyte, 22;STRL22
- Weitere Details:
- CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the B Beta defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.
- Versandbedingungen:
- Blue Ice