E-AB-F11330
Purified Anti-Human CD274/PD-L1 Antibody[29E.2A3], Functional Grade
Größe
£80.10
War £89.00
- SKU:
- E-AB-F11330
- Zusätzliche Namen:
- B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1,B7 homolog 1,B7-H,B7-H1,Programmed cell death ligand 1
- Anwendung:
- Flow Cytometry
- Konzentration:
- >= 1 mg/ml
- Aufreinigung:
- protein a/g purified
- Lagerbedingungen:
- 2-8[o]C Avoid freeze/thaw cycles., -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Mouse
- Reaktivitäten:
- Human
- Buffer:
- Sterile PBS, pH 7.2. < 1.0 EU per mg of the antibody as determined by the LAL method.
- Immunogen:
- Recombinant Human PD-L1 protein
- Klon:
- 29E.2A3
- Uniprot:
- Q9NZQ7
- Synonyme:
- B7 homolog 1;B7-H;B7H1;CD274 antigen;hPD-L1;PD-L1;PDCD1 ligand 1;PDCD1L1;PDCD1LG1;PDL1;programmed cell death 1 ligand 1
- Weitere Details:
- CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-G Gamma production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. None (Azide-Free,Low Endotoxin) are perfectly suited to be used in culture or in vivo (for nonhuman studies) for functional assays blocking, neutralizing, activation or depletion where the presence of azide may damage cells or exogenous endotoxin may signal or activate cells.
- Versandbedingungen:
- Blue Ice