E-AB-92278
UFL1 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-92278
- Zusätzliche Namen:
- KIAA0776, Maxer, RCAD,NLBP
- Anwendung:
- WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- Recombinant fusion protein of human UFL1
- Uniprot:
- O94874
- Synonyme:
- E3 UFM1-protein ligase 1;E3 UFM1-protein transferase 1;KIAA0776;LZAP-binding protein;Maxer;multiple alpha-helix protein located at ER;NLBP;novel LZAP-binding protein;RCAD;regulator of C53/LZAP and DDRGK1;Regulator of CDK5RAP3 and DDRGK1
- Weitere Details:
- E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to lysine residues on target proteins, and which plays a key role in reticulophagy (also called ER-phagy induced in response to endoplasmic reticulum stress. In response to endoplasmic reticulum stress, recruited to the endoplasmic reticulum membrane by DDRGK1, and mediates ufmylation of proteins such as RPN1 and RPL26/uL24, thereby promoting reticulophagy of endoplasmic reticulum sheets. Ufmylation-dependent reticulophagy inhibits the unfolded protein response (UPR via ERN1/IRE1-alpha. Ufmylation in response to endoplasmic reticulum stress is essential for processes such as hematopoiesis, blood vessel morphogenesis or inflammatory response. Regulates inflammation in response to endoplasmic reticulum stress by promoting reticulophagy, leading to inhibit the activity of the NF-kappa-B transcription factor (By similarity.
- Versandbedingungen:
- Blue Ice