E-AB-92210
CCR5 Polyclonal Antibody
Größe
£195.30
War £217.00
- SKU:
- E-AB-92210
- Zusätzliche Namen:
- CC-CKR-5, CCCKR5, CCR-5, CD195, CKR-5, CMKBR5, IDDM22,CKR5
- Anwendung:
- WB, IF
- Konzentration:
- 1 mg/ml
- Aufreinigung:
- Affinity Purified
- Lagerbedingungen:
- -20[o]C Avoid freeze/thaw cycles.
- Hersteller:
- Elabscience
- Host:
- Rabbit
- Reaktivitäten:
- Human, Mouse, Rat
- Buffer:
- Phosphate buffered solution, pH 7.4, containing 0.05% stabilizer and 50% glycerol.
- Immunogen:
- A synthetic peptide of human CCR5
- Uniprot:
- P51681
- Synonyme:
- C-C chemokine receptor type 5;C-C motif chemokine receptor 5 A159A;CC-CKR-5;CCCKR5;CCR-5;CD195;chemokine (C-C motif) receptor 5;chemokine receptor CCR5;chemokine recptor CCR5 Delta32;chemr13;CKR-5;CKR5;CMKBR5;HIV-1 fusion coreceptor;IDDM22;mutant C-C motif chemokine receptor
- Weitere Details:
- This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. This protein is expressed by T cells and macrophages, and is known to be an important co-receptor for macrophage-tropic virus, including HIV, to enter host cells. Defective alleles of this gene have been associated with the HIV infection resistance. The ligands of this receptor include monocyte chemoattractant protein 2 (MCP-2), macrophage inflammatory protein 1 alpha (MIP-1 alpha), macrophage inflammatory protein 1 beta (MIP-1 beta) and regulated on activation normal T expressed and secreted protein (RANTES). Expression of this gene was also detected in a promyeloblastic cell line, suggesting that this protein may play a role in granulocyte lineage proliferation and differentiation. This gene is located at the chemokine receptor gene cluster region. An allelic polymorphism in this gene results in both functional and non-functional alleles, the reference genome represents the functional allele. Two transcript variants encoding the same protein have been found for this gene.
- Versandbedingungen:
- Blue Ice